OMG Mischief makers is one of the classics. I mean, imagine if Mega Man were a girl, and instead of getting weapons to fire at evil robots, he grabbed and shook them all while saying the extremely cute line of "SHAKE SHAKE" One boss battle in paticulat has a boss throwing bad words at you like "Hate" "Rage" "Blood" and you grab the words, and by shaking them they turn into stuff like "Happy" "Cure" "Kindness" and then you throw them back and it deals MASSIVE DAMAGE.
One of my favorite childhood memories for N64